研究業績。ウイルス研究医学部の感染病態学教室

英文原著


1.Arai Y, Kawashita N, Hotta K, Hoang PVM, Nguyen HLK, Nguyen TC, Vuong CD, Le TT, Le MTQ, Soda K, Ibrahim MS, Daidoji T, Takagi T, Shioda T, Nakaya T, Ito T, Hasebe F, Watanabe Y**.

Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates.【こちら】

Sci Rep. 2018 Aug 30;8(1):13066. doi: 10.1038/s41598-018-31397-3.

2.Murakoshi F, Koyama K, Akasaka T, Horiuchi N, Kato K**.

Molecular and histopathological characterization of Cryptosporidium and Eimeria species in bats in Japan.【こちら】

J Vet Med Sci. 2018 Jul 16. doi: 10.1292/jvms.18-0130. [Epub ahead of print]

3.Takamura-Ishii M, Nakaya T, Hagiwara K**.

Regulation of Constitutive Interferon-Stimulated Genes (Isgs) in Tumor Cells Contributes to Enhanced Antitumor Response of Newcastle Disease Virus-Infected Tumor Vaccines.【こちら】

Cancers (Basel). 2018 Jun 6;10(6). pii: E186. doi: 10.3390/cancers10060186.

4.Takemae H, Kobayashi K, Sugi T, Han Y, Gong H, Ishiwa A, Recuenco FC, Murakoshi F, Takano R, Murata Y, Nagamune K, Horimoto T, Akashi H, Kato K**. Toxoplasma gondii RON4 binds to heparan sulfate on the host cell surface.【こちら】

Parasitol Int. 2018 Apr;67(2):123-130. doi: 10.1016/j.parint.2017.10.008. Epub 2017 Nov 20.

5.Watanabe Y**, Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Kajikawa J, Hiramatsu H, Sriwilaijaroen N, Ono T, Takagi T, Takahashi K, Shioda T, Matsumoto K, Suzuki Y, Nakaya T.

Characterization of H5N1 influenza virus quasispecies with adaptive hemagglutinin mutations from single-virus infections of human airway cells.【こちら】

J Virol. 2018 Mar 21. pii: JVI.02004-17. doi: 10.1128/JVI.02004-17. [Epub ahead of print]

6.Hirose R**, Nakaya T, Naito Y, Daidoji T, Yasuda H, Konishi H, Itoh Y.

Development of a new ex vivo model for evaluation of endoscopic submucosal injection materials performance.【こちら】

J Mech Behav Biomed Mater. 2018 Mar;79:219-225. doi: 10.1016/j.jmbbm.2018.01.002. Epub 2018 Jan 5.

英文原著

1. Kishida S, Nakaya T, Hagiwara K**.

Vaccination with Melanoma Cells Infected with Recombinant Newcastle Disease Virus Suppresses Tumor Metastasis.

SOJ Immunol 2017 Dec 4:5(3): 1-6.

2. Yamada M**, Shishito N, Nozawa Y, Uni S, Nishioka K, Nakaya T.

A combined human case of Dirofilaria ursi infection in dorsal subcutaneous tissue and Anisakis simplex sensu stricto (s.s.) infection in ventral subcutaneous tissue.【こちら】

Trop Med Health. 2017 Nov 1;45:26. doi: 10.1186/s41182-017-0067-4. eCollection 2017.

3. Takemae H, Kobayashi K, Sugi T, Han Y, Gong H, Ishiwa A, Recuenco FC, Murakoshi F, Takano R, Murata Y, Nagamune K, Horimoto T, Akashi H, Kato K**.

Toxoplasma gondii RON4 binds to heparan sulfate on the host cell surface.【こちら】

Parasitol Int. 2017 Oct 25. pii: S1383-5769(17)30312-4. doi: 10.1016/j.parint.2017.10.008.

4. Hirose R, Nakaya T**, Naito Y, Daidoji T, Watanabe Y, Yasuda H, Konishi H, Itoh Y.

Viscosity is an important factor of resistance to alcohol-based disinfectants by pathogens present in mucus.【こちら】

Sci Rep. 2017 Oct 13;7(1):13186. doi: 10.1038/s41598-017-13732-2.

5. Tsunekuni R, Hikono H, Tanikawa T, Kurata R, Nakaya T, Saito T.

Recombinant Avian Paramyxovirus Serotypes 2, 6, and 10 as Vaccine Vectors for Highly Pathogenic Avian Influenza in Chickens with Antibodies Against Newcastle Disease Virus.【こちら】

Avian Dis. 2017 Sep;61(3):296-306. doi: 10.1637/11512-100616-RegR1.

6. Matsubara R, Fukuda Y, Murakoshi F, Nomura O, Suzuki T, Tada C, Nakai Y**.

Detection and molecular status of Isospora sp. from the domestic pigeon (Columba livia domestica).【こちら】

Parasitol Int. 2017 Oct;66(5):588-592. doi: 10.1016/j.parint.2017.05.004. Epub 2017 May 8.

7. Takamura-Ishii M, Miura T, Nakaya T, Hagiwara K**.

Induction of antitumor response to fibrosarcoma by Newcastle disease virus-infected tumor vaccine.【こちら】

Med Oncol. 2017 Sep 1;34(10):171. doi: 10.1007/s12032-017-1034-y.

8. Daidoji T**, Watanabe Y, Arai Y, Kajikawa J, Hirose R, Nakaya T.

Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin.【こちら】

Viral Immunol.  (Review) 2017 Jul/Aug;30(6):398-407. doi: 10.1089/vim.2017.0020. Epub 2017 Jun 27.

9. Hirose R, Nakaya T**, Naito Y, Daidoji T, Watanabe Y, Yasuda H, Konishi H, Itoh Y.

Mechanism of Human Influenza Virus RNA Persistence and Virion Survival in Feces: Mucus Protects Virions From Acid and Digestive Juices.【こちら】

J Infect Dis. 2017 Jul 1;216(1):105-109. doi: 10.1093/infdis/jix224.

10. Hirose R, Nakaya T, Daidoji T**.

Long term detection of seasonal influenza RNA in faeces and intestine – Author’s Reply.

Clin Microbiol Infect. 2017 Apr;23(4):273-274. doi: 10.1016/j.cmi.2016.09.020.

11. Elgendy EM, Arai Y, Kawashita N, Daidoji T, Takagi T, Ibrahim MS, Nakaya T**, Watanabe Y**.

Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons.【こちら】

J Gen Virol. 2017 Jan;98(1):6-17. doi: 10.1099/jgv.0.000674.

12. Terkawi MA, Takano R, Furukawa A, Murakoshi F, Kato K**.

Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.【こちら】

Sci Rep. 2017 Feb 9;7:41772. doi: 10.1038/srep41772.

13. Shirasugi M, Nishioka K, Yamamoto T, Nakaya T**, Kanamura N.

Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. 【こちら】

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1122-1128.doi: 10.1016/j.bbrc.2016.11.168.

英文原著

1. Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Oda T, Konishi H, HiYamawaki M, Itoh Y, Nakaya T. Long term detection of seasonal influenza RNA in faeces and intestine.

Clin Microbiol Infect. 2016 Jul 14. pii: S1198-743X(16)30215-4. doi: 10.1016/j.cmi.2016.06.015.[Epub ahead of print]
2. Elgendy EM, Watanabe Y, Daidoji T, Arai Y, Ikuta K, Ibrahim MS, Nakaya T.Genetic characterization of highly pathogenic avian influenza H5N1 viruses isolated from naturally infected pigeons in Egypt.

Virus Genes. 2016 Jul 1.[Epub ahead of print]
3. Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy EM, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y.Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.

PLoS Pathog. 2016 Apr 20;12(4):e1005583. doi: 10.1371/journal.ppat.1005583

1. Hirose R, Daidoji T, Naito Y, Watanabe Y, Arai Y, Oda T, Konishi H, Yamawaki M, Itoh Y, Nakaya T. Long term detection of seasonal influenza RNA in faeces and intestine.

Clin Microbiol Infect. 2016 Jul 14. pii: S1198-743X(16)30215-4. doi: 10.1016/j.cmi.2016.06.015. [Epub ahead of print]

2. Elgendy EM, Watanabe Y, Daidoji T, Arai Y, Ikuta K, Ibrahim MS, Nakaya T. Genetic characterization of highly pathogenic avian influenza H5N1 viruses isolated from naturally infected pigeons in Egypt.

Virus Genes. 2016 Jul 1. [Epub ahead of print]

3. Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy EM, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y. Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses.

PLoS Pathog. 2016 Apr 20;12(4):e1005583. doi: 10.1371/journal.ppat.1005583

4. Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, Komori T, Okuzaki D, Narimatsu H, Nakaya T, Tomonaga K. Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.

J Virol. 2015 Dec 4;90(4):1788-801. doi: 10.1128/JVI.02246-15.

英文原著

1. Watanabe Y, Arai Y, Daidoji T, Kawashita N, Ibrahim MS, El-Gendy E, Hiramatsu H, Kubota-Kokestu R, Takagi T, Murata T, Takahashi K, Okuno Y, Nakaya T, Suzuki Y, Ikuta K. Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients.

mBio. 2015 Apr 7:. 6 (2). e00081-15. doi:10.1128/mBio.00081-15

2. Okamoto M, Miyazawa T, Morikawa S, Ono F, Nakamura S, Sato E, Yoshida T, Yoshikawa R, Sakai K, Mizutani T, Nagata N, Takano J, Okabayashi S, Hamano M, Fujimoto K, Nakaya T, Iida T, Horii T, Miyabe-Nishiwaki T, Watanabe A, Kaneko A, Saito A, Matsui A, Hayakawa T, Suzuki J, Akari H, Matsuzawa T, Hirai H. Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

Sci Rep. 2015 Mar 6;5:8850. doi: 10.1038/srep08850.

3. Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K, Nakaya T. Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH.

J Biol Chem. 2015 Feb 11. pii: jbc.M114.611327. [Epub ahead of print]

4. Motooka D, Nakamura S, Hagiwara K, Nakaya T. Viral detection by high-throughput sequencing.

Methods Mol Biol. 2015;1236:125-34. doi: 10.1007/978-1-4939-1743-3_11.

和文総説・著書

1. 中村昇太、飯田哲也・中屋隆明・堀井俊宏「感染症研究への次世代シーケンサーの応用」化学同人、2015年3月

英文原著

1. Soga K, Handa O, Yamada M, Sakagami J, Yagi N, Naito Y, Yoshikawa T, Itoh Y, Arizono N. In vivo imaging of intestinal helminths by capsule endoscopy.

Parasitology International, 63, 221-228, 2014.

2. Soga K, Yamada M, Naito Y, Yoshikawa T, and Arizono N. Mucin-related molecular responses of bronchial epithelial cells in rats infected with the nematode Nippostrongylus brasiliensis.

ISRN Parasitology, Article ID 804585, 8 pages, 2013.

3. Nicholas van Panchuys, Camberis M, Yamada M, Tegoshi T, Arizono N, and Graham Le Gros. Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6.

Parasitology, 140(7), 833-43, 2013.

4. Arizono N, Yamada M, Tegoshi T, Yoshikawa M. Anisakis simplex sensu stricto and Anisakis pegreffi: biological characteristics and pathogenetic potential in human anisakiasis.

Foodborne Pathog Dis. 9(6): 517-521, 2012.

5. Nonomura Y, Otsuka A, Endo Y, Fujisawa A, Nakajima N, Minamiguchi S, Miyagawa-Hayashino A, Yamada M, Tegoshi T, Yamasaki H, Kabashima K, Miyachi Y, Tanioka M. Sparganosis mansoni on abdominal shin, mimicking folliculitis and diagnosed by analysis of the mitochondrial cytochrome c oxidase subunit 1 gene, using polymerase chain reaction.Eur.

J. Dermatol. 22(6): 806-807, 2012.

6. Arizono N, Yamada M, Tegoshi T, Onishi K. Molecular identification of Oesophagostomum and Trichuris eggs isolated from wild Japanese macaques.

Korean J Parasit. 50(3): 253-257, 2012.

7. Yamada M, Tegoshi T, Abe N, Urabe M. Two human cases infected by the horsehair worm, Parachordodes sp. (Nematomorpha: Chordoidae), in Japan.

Korean J Parasit. 50(3): 263-267, 2012.

8. Yamasaki H, Muto M, Yamada M, Arizono N, Rausch RL. Validity of the bear tapeworm Diphyllobothrium ursi (Cestoda: Diphyllobothriidae) based on morphological and molecular markers.

J Parasit. 98(6): 1243-1247, 2012.

9. Arizono N, Miura T, Yamada M, Tegoshi T, Onishi K. Human infection with Pseudoterranova azarasi roundworm.Emerg.

Infect. Dis. 17(3): 555-556, 2011.

10. Isohisa T, Nakai N, Okuzawa Y, Yamada M, Arizono N, Katoh N. Case of tick bite with infestation of an extraordinary number of larval Amblyommma testudinarium ticks.

J. Dermtol. 38(11): 1110-1112, 2011.

11. Arizono N, Yamada M, Tegoshi T, Takaoka Y, Ohta M, Sakaeda T. Hsp12.6 expression is inducible by host immunity in adult worms of the parasitic nematode Nippostrongylus brasiliensis.

Plos ONE. 6(3), e18141: 1-12, 2011.

12. Takeda K, Hashimoto R, Uchikawa R, Tegoshi T, Yamada M, Arizono N. Direct effects of IL-4/IL-13 and the nematode Nippostrongylus brasiliensis on intestinal epithelial cells in vitro.

Parasite Immunol. 32: 420-429, 2010.

13. Soga K, Sakagami J, Handa O, Konishi H, Wakabayashi N, Yagi N, Yamada M, Kokura S, Naito Y, Yoshikawa T, Arizono N. Long fish tapeworm in the intestine: An in situ observation by capsule endoscopy.

Inter Med. 50: 325-327, 2010.

14. Arizono N, Yoshimura Y, Tohzaka N, Yamada M, Tegoshi T, Onishi K, Uchikawa R.Ascariasis in Japan: Is Pig-derived Ascaris infecting humanas?Jpn.

J. Infect. Dis. 63: 447-448, 2010.

15. Arizono N, Shedko M, Yamada M, Uchikawa R, Tegoshi T, Takeda K, Hashimoto K.Mitochondrial DNA divergence in populations of the tapeworm Diphyllobothrium nihoinkaiense and its phylogenetic relationship with Diphyllobothrium klebanovskii.

Parasitol Int. 58: 22-28, 2009.

16. Iguchi A, Yoshikawa H, Yamada M, Kimata I, Arizono N. Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystis sp. Strain RN94-9.

Parasitol Res. 105: 135-140, 2009.

17. Nara T, Katoh N, Inoue K, Yamada M, Arizono N, Kishimoto S. Eosinophilic folliculitis with a Demodex folliculorum infestation successfully treated with ivermectin in a man infected with human immunodeficiency virus.

Clin. Exp. Dermatol. 34: e981-983, 2009

18. Shimizu H, Kawakatsu H, Shimizu T, Yamada M, Tegoshi T, Uchikawa R, Arizono N. Diphyllobothriasis nihonkaiense : possibly acquired in Switzerland from imported Pacific salmon.

Inter. Med. 47: 1359-1362, 2008.

19. Arizono N, Fukumoto S, Tademoto S, Yamada M, Uchikawa R, Tegoshi T, Kuramochi T. Diplogonoporiasis in Japan: genetic analyses of five clinical isolates.

Parasitol Int. 57: 212-216, 2008.

20. Soga K, Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T, Mitsufuji S, Yoshikawa T, Arizono N. Alterlation of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis.

Parasitol Res. 103: 1427-1434, 2008.

英文著書

1. Morphology of human and animal Blastocystis isolates with special reference to reproductive modes.  Yamada M and Yoshikawa H.  Parasitology Monographs 4., H. Mehlhorn et al. (eds.),       Blastocystis : Pathogen or Passenger?, Springer-Verlag Berlin Heidelberg,  Chapter 2,  9-35, 2013.

和文総説・著書

標準臨床検査学 微生物学・臨床微生物学・医動物学. 一山 智・田中美智男編集. 医学書院. 医動物学(山田 稔)を分担執筆. p. 295-374, 2013年.

和文著書

    1.山田 稔、内川隆一、手越達也、大西弘太郎、有薗直樹、河原 敦、山本博文、児玉常憲、森田 豊、田代弘治. サル条虫Bertiella studeri 感染の2例.

    Clinical Parasitology. 20: 34-36, 2009.

    2.岩井泰博、大石哲也、山田 稔、有薗直樹、長谷川英男. 大腸漿膜下に腫瘤を形成した腸管外アニサキス症の1例.

    Clinical Parasitology. 20: 61-63, 2009.

    3.曽我幸一、福本晃平、小西英幸、若林直樹、吉川敏一、山田 稔、内川隆一、手越達也、有薗直樹. 直腸癌と鑑別を要したアメーバ性大腸炎の1例.

    Clinical Parasitology. 19: 30-32, 2008.

    4.阪上順一、辻 俊史、谷口浩也、片岡慶正、長谷川弘人、鈴木教久、信田みすみ、馬場武彦、土佐正俊、保田宏明、若林直樹、小西英幸、八木信明、小倉 聡、内藤裕二、吉田憲正、吉川敏一、十亀善生、内川隆一、手越達也、山田 稔、有薗直樹.

    カプセル内視鏡で観察した日本海裂頭条虫の1例.

    Clinical Parasitology. 19: 156-159, 2008.

    英文原著

    1. Watanabe Y, Ito T, Ibrahim MS, Arai Y, Hotta K, Phuong HV, Hang NL, Mai LQ, Soda K, Yamaoka M, Poetranto ED, Wulandari L, Hiramatsu H, Daidoji T, Kubota-Koketsu R, Sriwilaijaroen N, Nakaya T, Okuno Y, Takahashi T, Suzuki T, Ito T, Hotta H, Yamashiro T, Hayashi T, Morita K, Ikuta K, Suzuki Y. A novel immunochromatographic system for easy-to-use detection of group 1 avian influenza viruses with acquired human-type receptor binding specificity.

    Biosens Bioelectron. 2014 Oct 22;65C:211-219. doi: 10.1016/j.bios.2014.10.036.

    2. Niimi M, Masuda T, Kaihatsu K, Kato N, Nakamura S, Nakaya T, Arai F. Virus purification and enrichment by hydroxyapatite chromatography on a chip.

    Sensors and Actuators B: Chemical. 2014, 201:185-190.doi: 10.1016/j.snb.2014.04.011

    3. Pan Y, Sasaki T, Kubota-Koketsu R, Inoue Y, Yasugi M, Yamashita A, Ramadhany R, Arai Y, Du A, Boonsathorn N, Ibrahim MS, Daidoji T, Nakaya T, Ono KI, Okuno Y, Ikuta K, Watanabe Y. Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses.

    Biochem Biophys Res Commun.2014, Jul 18;450(1):42-8

    doi: 10.1016/j.bbrc.2014.05.060.

    4. Nakaya Y, Miyazawa T. Dysfunction of Bovine Endogenous Retrovirus K2 Envelope Glycoprotein Is Related to Unsuccessful Intracellular Trafficking.

    J. Virol. 2014, Jun 15; 88(12):6896-6905. doi: 10.1128/JVI.00288-14.

    和文総説・著書

    1    中屋隆明 ヒューマンパピローマウイルスの最新の話題. 京府医大誌 123(5), 319-324, 2014

    英文原著

    1. Yasugi M, Kubota-Koketsu R, Yamashita A, Kawashita N, Du A, Misaki R, Kuhara M, Boonsathorn N, Fujiyama K, Okuno Y, Nakaya T, Ikuta K.Emerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody.

    PLoS ONE. 2013 Oct 16;8(10):e77892. doi: 10.1371/journal.pone.0077892. eCollection 2013.

    2. Kaihatsu K, Sawada S, Nakamura S, Nakaya T, Yasunaga T, Kato N. Sequence-Specific and Visual Identification of the Influenza Virus NS Gene by Azobenzene-Tethered Bis-Peptide Nucleic Acid.

    PLoS ONE 2013 e64017. doi:10.1371/journal.pone.0064017.

    3. Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, Murakami M, Yoneda Y, Arai H, Kawaoka Y, Penninger JM, Arita M, Imai Y. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza

    Cell. 2013 Mar 28;153(1):112-25.

    4. Yasugi M, Kubota-Koketsu R, Yamashita A, Kawashita N, Du A, Sasaki T, Nishimura M, Misaki R, Kuhara M, Boonsathorn N, Fujiyama K, Okuno Y, Nakaya T, Ikuta K. Human Monoclonal Antibodies Broadly Neutralizing against Influenza B Virus.

    PLoS Pathog. 2013 Feb;9(2):e1003150.

    5. Monira S, Nakamura S, Gotoh K, Izutsu K, Watanabe H, Alam NH, Nakaya T, Horii T, Ali SI, Iida T, Alam M. Metagenomic profile of gut microbiota in children during cholera and recovery.

    Gut Pathog. 2013 Feb 1;5(1):1.

    和文総説・著書

    1    中屋隆明 鳥インフルエンザ. Neuroinfection 18(1), 28-33, 2013

    2    中屋隆明 インフルエンザウイルスHAタンパク質の病原性分子機構. 京府医大誌 122(3),123-131,総説, 2013

    英文原著

    1. Manríquez ME, Makino A, Tanaka M, Abe Y, Yoshida H, Morioka I, Arakawa S, Takeshima Y, Iwata K, Takasaki J, Manabe T, Nakaya T, Nakamura S, Iglesias AL, Rossales RM, Mirabal EP, Ito T, Kitazawa T, Oka T, Yamashita M, Kudo K,nya K. Emergence of HA mutants during influenza virus pneumonia.

    Int J Clin Exp Pathol. 2012;5(8):787-95.

    2. Watanabe Y, Ibrahim MS, Ellakany HF, Kawashita N, Daidoji T, Takagi T, Yasunaga T, Nakaya T, Ikuta K. Antigenic Analysis of Highly Pathogenic Avian Influenza Virus H5N1 Sublineages Co-Circulating in Egypt.

    J Gen Virol. 2012 Oct;93(Pt 10):2215-26.

    3. Ramadhany R, Yasugi M, Nakamura S, Daidoji T, Watanabe Y, Takahashi K, Ikuta K, Nakaya T**. Tropism of Pandemic 2009 H1N1 Influenza a Virus.

    Front Microbiol.3:128. 2012

    4. Yasugi M, Nakamura S, Daidoji T, Kawashita N, Ramadhany R, Yang CS, Yasunaga T, Iida T, Horii T, Ikuta K, Nakaya T**. Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010.

    PLoS ONE e30946, 2012.

    5. Monira S, Nakamura S, Gotoh K, Izutsu K, Watanabe H, Alam NH, Endtz HP, Cravioto A, Ali SI, Nakaya T, Horii T, Iida T, Alam M. Gut microbiota of healthy and malnourished children in bangladesh.

    Front Microbiol. 2:228.2011.

    6. Okumura Y, Takahashi E, Yano M, Ohuchi M, Daidoji T, Nakaya T, Bottcher E, Garten W, Klenk HD, Kido H: Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

    J Virol. 84: 5089-96, 2010.

    7. Umenai T, Hirai H, Shime N, Nakaya T, Asahara T, Nomoto K, Kita M, Tanaka Y, Imanishi J: Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide.

    Eur J Clin Microbiol Infect Dis. 29: 633-41, 2010.

    8. Ueda M, Daidoji T, Du A, Yang CS, Ibrahim MS, Ikuta K, Nakaya T**: Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells.

    J Virol. 84: 3068-78, 2010.

    9. Nakamura S, Yang CS, Sakon N, Ueda M, Tougan T, Yamashita A, Goto N, Takahashi K, Yasunaga T, Ikuta K, Mizutani T, Okamoto Y, Tagami M, Morita R, Maeda N, Kawai J, Hayashizaki Y, Nagai Y, Horii T, Iida T, Nakaya T**: Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach.

    PLoS ONE. 4: e4219, 2009.

    10. Kaihatsu K, Mori S, Matsumura H, Daidoji T, Kawakami C, Kurata H, Nakaya T, Kato N: Broad and potent anti-influenza virus spectrum of epigallocatechin-3-O-gallate-monopalmitate

    J Mol Genet Med. 3: 195-7, 2009.

    11. Du A, Daidoji T, Koma T, Ibrahim MS, Nakamura S, de Silva UC, Ueda M, Yang CS, Yasunaga T, Ikuta K, Nakaya T: Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody.

    Biochem Biophys Res Commun. 378: 197-202, 2009.

    12. Ueda M, Yamate M, Du A, Daidoji T, Okuno Y, Ikuta K, Nakaya T**: Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus.

    Virus Res. 136: 91-7, 2008.

    13. Mori S, Miyake S, Kobe T, Nakaya T, Fuller SD, Kato N, Kaihatsu K: Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length.

    Bioorg Med Chem Lett. 18: 4249-52, 2008.

    14. Li YG, Thawatsupha P, Chittaganpitch M, Rungrojcharoenkit K, Li GM, Nakaya T, Auwanit W, Ikuta K, Sawanpanyalert P: Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses.

    Biochem Biophys Res Commun. 371: 484-9, 2008.

    15. Li SM, Li GM, Nakamura S, Ikuta K, Nakaya T**: Reduced incorporation of SARS-CoV spike protein into viral particles due to amino acid substitutions within the receptor binding domain.

    Jpn J Infect Dis. 61: 123-7, 2008.

    16. Hagiwara K, Kadosawa T, Nakaya T.

    The Open Veterinary Science Journal, 2: 11-15, 2008.

    17. Daidoji T, Koma T, Du A, Yang CS, Ueda M, Ikuta K, Nakaya T**: H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells.

    J Virol. 82: 11294-307, 2008.

    英文著書

    Nakaya T, Nakamura S, Iida T, Horii T et al. Direct metagenomic detection of viral pathogens in human specimens using an unbiased high-throughput sequencing approach.

    Handbook of Molecular Microbial Ecology II, 73-82.Metagenomics in Different Habitats. Wiley-Blackwell, Hoboken, NJ, USA. 2011.

    英文総説

    1.Nakamura S, Nakaya T, and Iida T. Metagenomic analysis of bacterial infections by means of high-throughput DNA sequencing.

    Exp. Biol. Med. 236(8):968-971, 2011.

    2.Daidoji T, Kaihatsu K, Nakaya T. The role of apoptosis in influenza virus pathogenesis and the mechanisms involved in anti-influenza therapies.

    Current Chemical Biology 4:208-218, 2010.

    和文総説・著書

    1    中屋隆明 次世代シークエンサーのウイルス性疾患同定への適用. 臨床とウイルス 40(No.4):177-183, 2012

    2   中村昇太, 中屋隆明, 飯田哲也 メタゲノム解析を応用した網羅的病原体検出法. 最新医学 67(No.9):131-133, 2012

    3    中村昇太, 中屋隆明, 飯田哲也. 感染症のメタゲノミック診断. 化学療法の領域 27(No.9): 114-120, 2011

    4   中村昇太, 中屋隆明, 飯田哲也. 次世代シークエンサーを用いた感染症の診断と解析. メタゲノム解析技術の最前線. 服部正平編.(株)シーエムシー出版, 東京:pp160-168, 2010.

    5   中屋隆明.鳥インフルエンザ. 京府医大誌 114: 503-509, 2005.


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