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今村 俊彦

講師

専門領域 小児血液学/造血器腫瘍/分子生物学/造血幹細胞移植
学会専門医 日本小児科学会専門医/日本血液学会血液専門医・指導医/日本小児血液がん学会専門医・暫定指導医/骨髄移植財団移植調整医師/造血細胞移植認定医

経歴

平成6年3月 京都府立医科大学卒業
平成6年5月 京都府立医科大学小児科研修医
平成14年3月 京都府立医科大学大学院修了
平成14年4月 明石市民病院小児科
平成15年4月 松下記念病院小児科
平成16年9月 シカゴ大学内科血液腫瘍部門博士研究員
平成18年9月 京都府立医科大学小児科学教室助教
平成20年7月 京都府立医科大学小児科学教室学内講師
平成25年4月 京都府立医科大学小児科学教室 講師

受賞歴

第13回京都府立医科大学学友会青蓮賞
平成24年 小児医学研究振興財団研究助成
平成25年 公益信託日本白血病研究基金一般研究賞(クレディセゾン賞)

学会役員歴

  • 日本小児血液がん学会:評議委員・白血病リンパ腫委員
  • NPO法人日本小児がん研究グループ(JCCG):ALL委員・プロトコール・マニュアル委員・分子診断委員・監査委員
  • NPO法人日本小児白血病研究会(JACLS):運営委員・ALL委員委員長・AML委員
  • NPO法人LCH研究会副理事長

研究内容

  1. 小児難治性急性リンパ性白血病の遺伝子解析と治療標的の探索

  2. 急性骨髄性白血病の分化制御機構の解析と治療応用の検討

  3. MLL融合遺伝子の白血病発症機序の解析

代表的論文

  1. Yano M, Imamura T, Asai D, Kiyokawa N, Nakabayashi K, Matsumoto K, Deguchi T, Hashii Y, Honda YK, Hsegawa D, Sasahara Y, Ishii M, Kosaka Y, Kato K, Shima M, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K, Ichikawa H, Sato A. Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. Br J Haematol. 2015 Sep 25. doi: 10.1111/bjh.13757.

  2. Kawashima-Goto S, Imamura T, Tomoyasu C, Yano M, Yoshida H, Fujiki A, Tamura S, Osone S, Ishida H, Morimoto A, Kuroda H, Hosoi H. BCL2 Inhibitor (ABT-737): A Restorer of Prednisolone Sensitivity in Early T-Cell Precursor-Acute Lymphoblastic Leukemia with High MEF2C Expression? PLoS One. 10(7): e0132926, 2015. doi: 10.1371/journal.pone.0132926.

  3. Kawashima-Goto S, Imamura T, Seki M, Kato M, Yoshida K, Sugimoto A, Kaneda D, Fujiki A, Miyachi M, Nakatani T, Osone S, Ishida H, Taki T, Takita J, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Hosoi H. Identification of a homozygous JAK3 V674A mutation caused by acquired uniparental disomy in a relapsed early T-cell precursor ALL patient. Int J Hematol. 2014 Nov 28. [Epub ahead of print]

  4. Tuma Y, Imamura T, Ichise E, Sakamoto K, Ouchi K, Osone S, Ishida H, Wada T, Hosoi H. Successful treatment of idiopathic colitis related to XIAP deficiency with allo-HSCT using reduced-intensity conditioning. Pediatr Transplant. 2014. DOI: 10.1111/petr.12405

  5. Yano M, Imamura T, Asai D, Moriya-Saito A, Suenobu SI, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Hori H, Kosaka Y, Kato K, Horibe K, Yumura-Yagi K, Hara J, Matsumoto K, Kiyokawa N, Oda M, Sato A; for the Japan Association of Childhood Leukemia Study (JACLS). An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression. Genes Chromosomes Cancer. 2014; 53(10):815-23

  6. Sakamoto K, Imamura T, Yano M, Yoshida H, Fujiki A, Hirashima Y, Hosoi H. Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region. Blood Cancer Journal 4, e205; doi:10.1038/bcj.2014.25, 2014.

  7. Asai D, Imamura T, Yamashita Y, Suenobu S, Moriya-Saito A, Hasegawa D, Deguchi T, Hashii Y, Endo M, Hatakeyama N, Kawasaki H, Hori H, Horibe K, Yumura-Yagi K, Hara J, Watanabe A, Ki Kikuta A, Oda M, Sato A. Outcome of TCF3-PBX1 positive pediatric acute lymphoblastic leukemia patients in Japan: a collaborative study of Japan Association of Childhood Leukemia Study and Children’s Cancer and Leukemia Study Group. Cancer Medicine doi: 10.1002/cam4.221, 2014.

  8. Asai D, Imamura T, Suenobu S, Saito A, Hasegawa D, Deguchi T, Hashii Y, Matsumoto K, Kawasaki H, Hori H, Iguchi A, Kosaka Y, Kato K, Horibe K, Yumura-Yagi K, Hara J, Oda M. IKZF1 deletion is associated with a poor outcome in pediatric B-cell precursor acute lymphoblastic leukemia in Japan. Cancer Medicine. 2: 412-419, 2013

  9. Yoshida H, Imamura T, Fujiki A, Hirashima Y, Miyachi M, Inukai T, Hosoi H. Post-transcriptional modulation of C/EBPα prompts monocytic differentiation and apoptosis in acute myelomonocytic leukaemia cells. Leuk Res. 36; 735-741, 2012.

  10. Fujiki A, Imamura T, Sakamoto K, Kawashima S, Yoshida H, Hirashima Y, Miyachi M, Yagyu S, Nakatani T, Sugita K, Hosoi H. All-trans retinoic acid combined with 5-Aza-2'-deoxycitidine induces C/EBPα expression and growth inhibition in MLL-AF9-positive leukemic cells. Biochem Biophys Res Commun. 428: 216-223, 2012

  11. Imamura T, Iwamoto S, Kanai R, Shimada A, Terui K, Osugi Y, Kobayashi R, Tawa A, Kosaka Y, Kato K, Hori H, Horibe K, Oda M, Adachi S. Outcome in 146 patients with paediatric acute myeloid leukaemia treated according to the AML99 protocol in the period 2003-06 from the Japan Association of Childhood Leukaemia Study. Br J Haematol. 159: 204-210, 2012

  12. Imamura T, Sato T, Shiota Y, Kanegane H, Kudo K, Nakagawa S, Nakadate H, Tauchi H, Kamizono J, Morimoto A. Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine: a nationwide survey in Japan. Int J Hematol. 91 (4): 646-651, 2010

  13. Nakatani T, Imamura T, Ishida H, Wakaizumi K, Yamamoto T, Otabe O, Ishigami T, Adachi S, Morimoto A. Frequency and clinical features of the JAK2 V617F mutation in pediatric patients with sporadic essential thrombocythemia. Pediatr Blood Cancer. 51(6): 802-805, 2008.

  14. Imamura T, Yoshihara T, Morimoto A, Ishida H, Sugimoto T, Imashuku S. Successful autologous peripheral blood stem cell transplantation with rituximab administration for pediatric diffuse large B-cell lymphoma. Pediatr Hematol Oncol. 23(1): 19-24, 2006.

  15. Imamura T, Morimoto A, Kato R, Izumi M, Murakami A, Matuo S, Kiyosawa N, Kano G, Yoshioka H, Sugimoto T, Imashuku S. Cerebral thrombotic complications in adolescent leukemia/lymphoma patients treated with L-asparaginase-containing chemotherapy. Leuk Lymphoma. 46(5): 729-735, 2005.

  16. Imamura T, Matsuo S, Yoshihara T, Chiyonobu T, Mori K, Ishida H, Nishimura Y, Kasubuchi Y, Naya M, Morimoto A, Hibi S, Imashuku S. Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation. Int J Hematol. 80(2): 186-189, 2004.

  17. Imamura T, Kakazu N, Hibi S, Morimoto A, Fukushima Y, Ijuin I, Hada S, Kitabayashi I, Abe T, Imashuku S. Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11). Genes Chromosomes Cancer. 36: 413-419, 2003.

  18. Imamura T, Morimoto A, Takanashi M, Hibi S, Sugimoto T, Ishii E, Imashuku S. Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement. Br J Haematol. 119(1): 119-121, 2002.

  19. Imamura T, Morimoto A, Ikushima S, Kakazu N, Hada S, Tabata Y, Yagi T, Inaba T, Hibi S, Sugimoto T, Imashuku S. A novel infant acute lymphoblastic leukemia cell line with MLL-AF5q31 fusion transcript. Leukemia. 16(11): 2302-2308, 2002.

  20. Yagi T, Hibi S, Takanashi M, Kano G, Tabata Y, Imamura T, Inaba T, Morimoto A, Todo S, Imashuku S. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood. 99(4): 1350-1355, 2002.