研究のご案内

神経グループ

研究室のご紹介

臨床研究

  • 拡散テンソル画像などの先進的MRIを用いた小児神経疾患の解析(本学放射線医学教室との共同研究)
  • 乳幼児てんかんの診断と治療

基礎研究

  • 遺伝性神経疾患の分子生物学的診断と病態解析

研究メンバー

看護学科医学講座小児科学 教授 森本昌史
特任准教授 西村 陽(京都第一赤十字病院)
学内講師 千代延友裕(京都府立医大附属北部医療センター)
助教 長谷川龍志
助教 吉田路子
助教 森田高史(京都府立舞鶴こども療育センター)
大学院生 瑞木 匡

関係学会

  • 日本小児神経学会
  • 日本てんかん学会
  • 日本人類遺伝学会

学会認定施設

  • 小児神経専門医制度認定研修施設
  • てんかん専門医制度認定研修施設
  • 臨床遺伝専門医制度認定研修施設

業績

  1. Kidowaki S, Morimoto M, Yamada K, Sakai K, Zuiki M, Maeda H, Yamashita S, Morita T, Hasegawa T, Chiyonobu T, Tokuda S, Hosoi H. Longitudinal change in white matter in preterm infants without magnetic resonance imaging abnormalities: Assessment of serial diffusion tensor imaging and their relationship to neurodevelopmental outcomes. Brain Dev. 2017; 39: 40-7.

  2. Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H. Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy. Epilepsia. 2016; 57: e81-6.

  3. Maeda H, Chiyonobu T, Yoshida M, Yamashita S, Zuiki M, Kidowaki S, Isoda K, Yamakawa K, Morimoto M, Nakahata T, Saito MK, Hosoi H. Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome. J Hum Genet. 2016; 61(6):565-9.

  4. Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito MK. Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs. Stem Cell Reports. 2015; 4: 561-8.

  5. Morita T, Morimoto M, Yamada K, Hasegawa T, Morioka S, Kidowaki S, Moroto M, Yamashita S, Maeda H, Chiyonobu T, Tokuda S, Hosoi H. Low-grade intraventricular hemorrhage disrupts cerebellar white matter in preterm infants: evidence from diffusion tensor imaging. Neuroradiology. 2015; 57: 507-14.

  6. Moroto M, Nishimura A, Morimoto M, Isoda K, Morita T, Yoshida M, Morioka S, Tozawa T, Hasegawa T, Chiyonobu T, Yoshimoto K, Hosoi H. Altered somatosensory barrel cortex refinement in the developing brain of Mecp2-null mice. Brain Res. 2013; 1537: 319-26.

  7. Morioka S, Morimoto M, Yamada K, Hasegawa T, Morita T, Moroto M, Isoda K, Chiyonobu T, Imamura T, Nishimura A, Morimoto A, Hosoi H. Effects of chemotherapy on the brain in childhood: diffusion tensor imaging of subtle white matter damage. Neuroradiology. 2013; 55: 1251-7.

  8. Tozawa T, Itoh K, Yaoi T, Tando S, Umekage M, Dai H, Hosoi H, Fushiki S. The shortest isoform of dystrophin (Dp40) interacts with a group of presynaptic proteins to form a presumptive novel complex in the mouse brain. Mol Neurobiol. 2012; 45: 287-97.

  9. Hasegawa T, Yamada K, Morimoto M, Morioka S, Tozawa T, Isoda K, Murakami A, Chiyonobu T, Tokuda S, Nishimura A, Nishimura T, Hosoi H. Development of corpus callosum in preterm infants is affected by the prematurity: in vivo assessment of diffusion tensor imaging at term-equivalent age. Pediatr Res. 2011; 69: 249-54.

  10. Isoda K, Morimoto M, Matsui F, Hasegawa T, Tozawa T, Morioka S, Chiyonobu T, Nishimura A, Yoshimoto K, Hosoi H. Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice. Neuroscience. 2010; 165: 1254-60.

  11. Matsui F, Morimoto M, Yoshimoto K, Nakatomi Y, Syoji H, Nishimura A, Isoda K, Tanda K, Hosoi H. Effects of stress of postnatal development on corticosterone, serotonin and behavioral changes. Brain Dev. 2010; 32: 517-23.