研究室の業績 (2008年以降)
原著論文・総説
2018年
Yamashita W. Takahashi M. Kikkawa T. Gotoh H. Osumi N. Ono K. Nomura T. (2018) Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.
Development 145,dev159764.doi:10.1242/dev.159764.
Sato K, Yamashita T, Ohuchi H, Takeuchi A, Gotoh H, Ono K, Mizuno M, Mizutani Y, Tomonari, S, Sakai K, Imamoto Y, Wada A, Shichida Y. (2018) Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor.
Nature Communications 9, 1255.
Nomura T. Yamashita W. Gotoh H. Ono K. (2018) Species-specific mechanisms of neuron subtype specification reveal evolutionary plasticity of amniote brain development.
Cell Reports 22, 3142-3151.
Ono K. Hirahara Y. Gotoh H. Nomura T. Takebayashi H. Yamada H. Ikenaka K. (2018) Origin of oligodendrocytes in the vertebrate optic nerve: a review.
Neurochemical Research
43(1): 186-194.
Nomura T. Gotoh H. Ono K. (2018) The future vocation of neural stem cells: lineage commitment in brain development and evolution.
Neurochemical Research
43(1): 153-156.
2017年

Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K. (2017) Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area.
Brain Structure and Function. 222(5):2441-2448. doi: 10.1007/s00429-017-1394-2.

Hirahara Y, Wakabayashi T, Mori T, Koike T, Yao I, Tsuda M, Honke K, Gotoh H, Ono K, Yamada H.(2017) Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry.
Journal of Neurochemstry 140(3):435-450.
Gotoh H. Nomura T. Ono K. (2017) Glycogen serves as an energy source that maintains astrocyte cell proliferation in the neonatal telencephalon.
Journal of Cerebral Blood Flow and Metabolism 37(6): 2294-2307.
Yamashita W. Shimizu T. Nomura T. (2017) In vivo and ex ovo culture of reptilian and avian neural progenitor cells.
Methods in Molecular Biology: Avian and Reptilian Developmental Biology
Springer pp259-267.
Nomura T. Izawa E-I. (2017). Avian brains: insights from development, behaviors and evolution.
Development Growth and Differentiation 59(4): 244-257.
Nomura T. HIrata T. (2017) The neocortical homologues in non mammalian amniotes: bridging the hierarchical concepts of homology through comparative neurogenesis.
In Evolution of Nervous Systems 2nd Edition. Ed: John H. Kaas. Elsevier pp195-204.
Yamashita W. Nomura T. The neocortex and dorsal ventricular ridge: functional convergence and underlying developmental mechanisms.
In Brain Evolution by Design -From Neural Origin to Cognitive Architecture
Ed: Shigeno S. Murakami Y. and Nomura T. Chapter 13.
Zuiki M, Chiyonobu T, Yoshida N, Maeda H, Yamashita S, Kidowaki S. Hasegawa T, Gotoh H, Nomura T, Ono K, Hosoi H, Morimoto M. (2017). Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: a candidate preventive substance for maternal immune activation-induced abnormalities.
Neuroscience Letters 653: 296-301.
小野勝彦、後藤仁志、野村真 (2017) ゾウリムシの維持とこれを使った生物学実習 Studia Humana et Naturalia 50: 41-47..
野村真 (2017) 生命科学実験動物としてのソメワケササクレヤモリの飼育・繁殖方法 Studia Humana et Naturalia 50: 49-56.
2016年

Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MI, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.(2016) Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality.
Neurobiology of Disease 96:271-283
.

Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Ikenaka K, Hitoshi S. (2016) The dorsoventral boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal window.
Cerebral Cortex 26(6):2800-10.

Nomura T, Nishimura Y, Gotoh H, Ono K. 2016 Rapid and efficient gene delivery into the adult mouse brain via focal electroporation.
Scientific Reports 2016 Jul 19;6:29817.
Nomura T, Ohtaka-Maruyama C, Yamashita W, Wakamatsu Y, Murakami Y, Calegari F, Suzuki K, Gotoh H, Ono K. (2016) The evolution of basal progenitors in the developing non-mammalian brain. Development. 143(1):66-74.
2015年
Fukushima S, Nishikawa K, Furube E, Muneoka S, Takebayashi H, Ono K, and Miyata S. (2015) Oligodendrogenesis in the fornix of adult mouse brain; the effect of LPS-induced inflammatory stimulation. Brain Rsearch 1627: 52-69.

Nomura T, Yamashita W, Gotoh H, Ono K. (2015) Genetic manipulation of reptilian embryos: toward an understanding of cortical development and evolution.
Frontiers in Neuroscience.;9: 45.

小野勝彦、山内菜緒、後藤仁志、吉井健悟、野村真 (2015) 腹側視床の形成と視床皮質線維のガイダンス.Studia Humana et Naturalia, 49,31-40, 2015
2014年
Horie M, Watanabe K, Bepari AK, Nashimoto J, Araki K, Sano H, Chiken S, Nambu A, Ono K, Ikenaka K, Kakita A, Yamamura K, Takebayasi H. (2014) Disruption of dystonin protein containing actin-binding domain cause dystonia musculorum in mice.
European Journal of Neuroscience 40(10): 3458-3471.

Ono K, Clavairoly A, Nomura T, Gotoh H, Uno A, Armant O, Takebayashi H, Zhang Q, Shimamura K, Itohara S, Parras CM, Ikenaka K. (2014)  Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.
Development 141, 1075-1084

Nomura T. Hanashima C. (2014) Neocortical development and evolution.
Neuroscience Research 86:1-2 
Nomura T, Murakami Y, Gotoh H, Ono K.(2014) Reconstruction of ancestral brains: exploring the evolutionary process of encephalization in amniotes.
Neuroscience Research 86: 25-36.
Yamashita T, Ono K, Ohuchi H, Yumoto A, Gotoh H, Tomonari S, Sakai K, Fujita H, Imamoto Y, Noji S. Nakamura K, Shichida Y.(2014) Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation.
Journal of Biological Chemistry
, 289, 3991-4000
Wakamatsu Y, Nomura T, Osumi N, Suzuki K. (2014). Comparative gene expression analyses reveal heterochrony for Sox9 expression in the cranial neural crest during marsupial development.
Evolution & Development 16(4):197-206.

後藤仁志 野村真 小野勝彦 (2014) 細胞内エネルギー代謝と生理機能Studia Humana et Naturalia, 48, 79-77.

小野勝彦 後藤仁志 野村真(2014Olig2による間脳の領域形成 Studia Humana et Naturalia, 48, 63-70

野村真 (2014) 哺乳類大脳皮質の拡大をもたらした分子機構の解明:進化発生学、幹細胞生物学を基盤とした研究戦略の試み 京都府立府立医科大学雑誌 123(9): 607-616.
2013
Nomura T, Gotoh H, Ono K. (2013) Changes in the regulation of cortical neurogenesis contribute to enephalization during amniote brain evolusion.
Nature Communications 4, 2206.
Shimizu T, Tanaka KF, Takebayashi H, Higashi M, Wisesmith W, Ono K, Hitoshi S, Ikenaka K.(2013) Olig2 lineage cells preferentially differentiate into oligodendrocytes but their processes degenrate at the chronic demyelinating stage of PLP-overexpressing mouse. J Neurosci Ressearch 91, 1758-186.
小野勝彦、伊藤啓 (2013) グリア細胞の発生.脳の発生学(宮田、山本編)、化学同人186-202
Nomura T, Kawaguchi M, Ono K, Murakami Y.(2013) Reptiles: a new model for brain evo-devo research.
Journal of Experimental Zoology Part B Molecular and developmental evolution 320, 57-73.
後藤仁志、小野勝彦(2013)中枢神経系における細胞分化と系譜解析.京都府立医科大学雑誌、122、316-370.
2012
Ono K, and Ikenaka K (2012). Lineage and development: Oligodendrocytes. 
In “Neuroglia” Third edition Kettenman H, and Ransom B Eds. pp.148-158.
小野勝彦、後藤仁志、上田貴之 (2012) ニワトリ胚における髄鞘形成細胞について.Studia Humana et Naturalia, 46, 55-63. Humana46_ono.pdf へのリンク
野村真 (2012) 脳の「皺」は何故できるのか?-その発生進化的メカニズム-.Studia Humana et Naturalia, 46, 65-76.humana46_nomura.pdf へのリンク
Gotoh H, Ono K, Nomura T, Takebayashi H, Harada H, Nakamura H, Ikenaka K.(2012) Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
PLos ONE, 7, e51581.
Usui N, Watanabe K, Ono K, Tomita K, Tamamaki N, Ikenaka K, Takebayashi H. (2012). Role of motoneuron-derived NT-3 in survival and axonal projection of sensory neurons during neural circuit formation.
Development  139, 1125-1132
野村真 (2012) 胚操作による実験進化発生学-非モデル動物を用いたフェノコピー創出実験.Studia Humana et Naturalia, 45, 53-64.
2011
Matsumoto Y, Tsunekawa Y, Nomura T, Suto F, Matsumata M, Tsuchiya S, Osumi N.(2011) Differential proliferation rhythm of neural progenitor and oligodendrocyte precursor cells in the young adult hippocampus.
PLoS ONE 6 (11): e27628.
Gotoh H, Ueda T, Uno A, Ohuchi H, Ikenaka K, Ono K.(2011) Expression of myelin genes in the developing chick retina.
Gene Expression Pattern
11,471-5.
 Gotoh H, Ono K, Takebayashi H, Harada H, Nakamura H, Ikenaka K. (2011) Lineage tracing of Nkx2.2-expressing cells by genetically-defined lineage tracing method in chick spinal cord.Developmental Biology 349(2): 504-511. 

Inamura N, Ono K, Takebayashi H, Zalc B, Ikenaka K. (2011) Olig2-lineage cells generate GABAergic neurons in the prethalamic nuclei, including the zona incerta, ventral lateral geniculate nucleus and reticular thalamic nucleus..
Developmental Neuroscience 33: 118-29

Kim WR, Chun SK, Kim TW, Kim H, Ono K, Takebayashi H, Ikenaka K,(2011) Oppenheim RW, Sun W. Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain.
European Journal of Neuroscience 33(4):599-611.
2010
Shibasaki k, Maruyama N, Ono K, Ishizuka Y, Tominga M. TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons.
Journal of Neuroscience 30: 4601-4612
Murakami S, Ohki-Hamasaki H, Watanabe K, Ikenaka K, Ono K. (2010) Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain.
Journal of Comperative Neurology 518: 2019-2034.
2009年
Ono, K., Takebayashi, H., Ikenaka, K. (2009) Olig2 transcription factor in the developing and injured forebrain: Cell lineage and glial development.
Molecules and .Cells 27: 397-401
小野勝彦、渡辺啓介 ネトリンシグナルと脊髄背側部の形成 京都府立医大誌 118(2): 77-85.
Masuda T, Yaginuma H, Sakuma C, Ono K. Netrin-1 and signaling for sensory axons. Involvement in sensory axonal development and regeneration (commentary & view).
Cell Adhesion and Migration
2008年
Publications
Takebayashi H, Usui N, Ono K, Ikenaka K.(2008) Tamoxifen modulates apoptosis in multiple modes of action in CreER mice.
Genesis 46, 775-781.
Masuda T, Watanabe K, Sakuma C, Ikenaka K, Ono K, Yaginuma H.(2008). Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.
Journal of Neuroscience 28: 10380-10385.
Ono K, Takebayashi H, Ikeda K, Furusho M, Nishizawa T, Watanabe K, Ikenaka K.(2008). Regional- and Temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium.
Developmental Biology 320(2):456-68.
Jin E, Sano M.(2008) Neurite outgrowth of NG108-15 cells induced by heat shock protein 90 inhibitors.
Cell Biochemical Function.;26(8):825-32
佐野護 生物学の研究、彷徨からの呟き 京都府医大誌 117:507-515, 2008